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Metformin inhibits mitochondrial complex 1. Cyanide blocks mitochondrial complex 4.

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  • Metformin inhibits mitochondrial complex 1. Cyanide blocks mitochondrial complex 4.

    If you didn't already know it, you now know something that doctors could appreciate since they speak the language.

  • #2
    Sir, this is a Wendy's.

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    • #3
      Made me look.

      https://www.centerforhealthsecurity....ide-fact-sheet

      Says one antidote to cyanide poisoning is hydroxycobalamin, which bonds to cyanide and becomes... cyanocobalamin (Vitamin B12). Cool.

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      • #4
        Is this gonna be on a pop quiz later?

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        • #5
          What’s a mitochondria?

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          • #6
            Originally posted by FIREshrink View Post
            Made me look.

            https://www.centerforhealthsecurity....ide-fact-sheet

            Says one antidote to cyanide poisoning is hydroxycobalamin, which bonds to cyanide and becomes... cyanocobalamin (Vitamin B12). Cool.
            Body also makes rhodanese:
            https://en.wikipedia.org/wiki/Rhodanese

            So accidentally nibbling on the occasional apple seed is fine. Was wondering where the name comes from. rhodanide is -SCN(Thiocyanate). rho is greek base for rose. Iron plus cyanide gives you that red rose color.

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            • #7
              Originally posted by xraygoggles View Post
              Is this gonna be on a pop quiz later?
              Click image for larger version

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              What I find cool is that kids are being educated early about the mitochondria. In junior high, then in high school. The content seems advanced even dabbling into ochem. Old people like me boomers and genx are clueless.

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              • #8
                Do they still call it the powerhouse of the cell?

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                • #9
                  Oooh thanks for the tips, I am low in B12 anyone got some spare apricot kernels for me?

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                  • #10
                    Originally posted by Lordosis View Post
                    Do they still call it the powerhouse of the cell?
                    They do.



                    "Hey Dad or Mom, how does cyanide kill you?"

                    1. I don't know. Google it.
                    2. Some ahole on WCI won't shut up about it. Something to do with something or other. Why are you pimping me, I'm only a doctor.
                    3. It blocks Complex 4 on the mitochondria and you run out of energy. Mic drop.

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                    • #11
                      1: So cyanide replaces metformin for diabetes treatment?

                      2: My organic chemistry teacher said he always kept chocolate with him to reverse cyanide poisoning. He complained to the Dean because the football coach got new equipment but he didn't get a new mass spectrometer. He said the coach was going to poison him now.

                      That's all I got.
                      $1 saved = >$1 earned. ✓

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                      • #12
                        Reminds me of how much I don’t miss med school.

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                        • #13
                          Originally posted by Cubicle View Post
                          1: So cyanide replaces metformin for diabetes treatment?
                          No. I just though it an interesting take. Always wondered why pharma didn't produce some metfomin equivalent medication.

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                          • #14
                            Originally posted by Cubicle View Post
                            1: So cyanide replaces metformin for diabetes treatment?
                            Well, it certainly works as a cure (of diabetes, and any other metabolic dysfunction). The side effects of the cure are a bit rough, though...

                            ************************ this board! Now I need to go look up the differences between mitochondrial complex 1 and mitochondrial complex 4, and I am already busy!

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                            • #15
                              Chlorophyll, more like Borophyll

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