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  • Originally posted by Kamban View Post

    I would like to see the published data that a 3rd dose of Pfizer boosts you up to come up to the Moderna level of protection which had only 2 doses given.

    Maybe it would have been nice to have a randomized trial of booster for the original 2 dose Pfizer with either a 3rd dose of Pfizer or switching to Moderna for the 3rd dose. I bet Pfizer would not have liked that in case the its booster showed inferior results.

    Call me a cynic but I am losing confidence in the Pfizer's vaccine, which initially promised high effectiveness but it fell off the cliff rapidly. As I had stated earlier I changed horses and took Moderna as my 3rd dose after getting 2 doses of Pfizer in Dec 2020/Jan 2021.


    There is one that I know of which includes NYU as a site. Considered it, but the number of lab draws required at their site wouldve made it intolerable to participate in while working.

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    • Originally posted by shady View Post

      I received my 3rd Moderna vax ~4 weeks ago. At the time I was a bit nervous but I figured it was inevitable and risk to benefit was in my favor. Minimal side effect and I think the more data that comes out the more beneficial it appears.

      People's continued negligence with the disease is completely mind blowing. Our clinic office manager appeared sick Tuesday when walking into my office. Of course mask down until they walked in then put it up. Right away I thought COVID. Wednesday I get an email saying they are working remotely and tested positive for COVID. Turns out their spouse was at home sick with COVID and they were actively working in the clinic, intermittent masking, and informed nobody. At the very least mask 100% and honestly stay in your office and try to avoid other people. Seems even medical people fall victim to denial when they get sick.
      If she's vaccinated isn't CDC guidance that she does not need to quarantine?

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      • Originally posted by FIREshrink View Post

        If she's vaccinated isn't CDC guidance that she does not need to quarantine?
        No, she was symptomatic before she got the COVID test, and had a known exposure. She should have stayed home. Here's a quote from the relevant part of the CDC's COVID information for fully vaccinated people ( https://www.cdc.gov/coronavirus/2019...accinated.html - look under the subsection "What You Should Keep Doing"):

        "You should still watch out for symptoms of COVID-19, especially if you’ve been around someone who is sick. If you have symptoms of COVID-19, you should get tested and stay home and away from others. If your test is positive, isolate at home for 10 days.."

        Right now a URI should be presumed to be COVID until a test comes back negative. That ought to be common sense, but it clearly isn't.

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        • I didn't pick up that she was symptomatic and awaiting a test result

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          • Originally posted by snowcanyon View Post

            I did the same. I'm heartbroken my elderly parents had to get a third dose of Pfizer, but they were told that was the only option, they couldn't switch to Moderna.
            I got a Moderna booster and am contemplating finishing the Moderna series.
            Yeah, I'm not really following the minute by minute studies, but I'm just not worried about it. I got a 3rd dose of Pfizer because of peer pressure (that is what most of my colleagues were doing because of a number of breakthrough cases, and nobody wanted the inconvenience). Honestly, a year ago at this time I was worried that I or some of my partners would be dead by the end of the year. And now, we are worried about inconvenience!

            I felt worse with each successive dose of the mRNA vaccine. There is just no way that I'm going to screw around with this until there is a more convincing risk/reward profile. I'd rather quarantine for 7 days with a sniffle than feel like over-warmed dog feces for 2 days nor deal with mobility hindering adenopathy. (Or longer if the side effect trend continues.)

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            • I didn't see any direct mention for health care workers to get booster. Just over 65 and illness related.

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              • Originally posted by Lordosis View Post
                I didn't see any direct mention for health care workers to get booster. Just over 65 and illness related.
                if I understand it correctly the recommendation today was Pfizer-only if 6 months or longer from last vaccine, all pts 65 or over, 18-64 if you have a risk factor (obesity, etc). My guess is that most people 18-64 can get one if they want one. Frankly I'm not clear who has the final word though, it seems like there is a new committee and recommendation every time you turn around.

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                • Originally posted by artemis View Post

                  You know, I really do wonder if the winning trifecta will turn out to be one dose of an adenovirus vector vaccine (to boost T-cell mediated immunity) + one dose of an mRNA vaccine (to boost humoral immunity) + one dose of a killed virus vaccine (to expose the immune system to other epitopes besides the spike protein). I guess we'll have to wait and see what works best.
                  Probably throw in a break through or previous natural infection and that is about all you can do. Oh, I forgot. Mask and keep social distancing and wash your hands!
                  Possibly double mask. And then maybe some treatments, just in case, on a preventative basis.

                  Bottom line is I don't want Covid. Feel free to add anything else. I got some steroid cream at home. Probably won't do crap, but I am desperate. Not being a cynic, but I wish I could find just how much each step is effective.

                  My hesitation is intentionally getting covid for the natural protection. Educate me on how effective that is please. Right or wrong, all of those seem to have narratives that they can actually produce some benefit. I just don't know.

                  I will probably wait until Moderna is approved for a booster and just stay home.

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                  • Originally posted by Rando View Post

                    if I understand it correctly the recommendation today was Pfizer-only if 6 months or longer from last vaccine, all pts 65 or over, 18-64 if you have a risk factor (obesity, etc). My guess is that most people 18-64 can get one if they want one. Frankly I'm not clear who has the final word though, it seems like there is a new committee and recommendation every time you turn around.
                    Nope same committees.

                    ​​​​​​FDA move then ACIP rec then CDC final.

                    FDA was yesterday
                    ACIP rarely goes contrary to FDA but they did today on HCW or other high risk exposures.

                    They had little data for NNT on it so there was quite a heated debate on following the lack of science available.

                    CDC final is up.tomorrow. they may ignore the ACIP recs today.....who knows.


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                    • Originally posted by Lordosis View Post
                      I didn't see any direct mention for health care workers to get booster. Just over 65 and illness related.
                      You are correct. The FDA recommended it but the CDC decided in their vote not to include healthcare workers. A lot changes in a day I guess.

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                      • But Dr. Wallensky overruled. High risk occupations included.

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                        • Having just had covid myself I am sorta boosted already. I will get the booster if available to me this fall but I am not anxious about it.

                          However I think it is a mistake to not include high risk occupations. We are already looking down the barrel at a staff shortage. Why not do all we can to prevent illness and avoidable quarantines?

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                          • ACIP is quite conservative in nature and simply put, the data isn't there for widespread usage of vaccine in high exposure for vaccine booster for hospitalization.
                            THere was heater debate on exactly Lordosis point from the staffing point to minimize breakthroughs. That was same issue at hand in the FDA and large reason for a statement vs vote on it.

                            ​​​​​​​CDC may end up rec it regardless but that'll be a policy call moreso than a science based call.

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                            • Can you just walk into a Wallgreens, CVS, etc. today and ask for a vaccine due to occupational exposure? Will they say no?

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                              • Originally posted by FunkDoc83 View Post
                                Can you just walk into a Wallgreens, CVS, etc. today and ask for a vaccine due to occupational exposure? Will they say no?
                                I think they would decline the request. There are other qualifiers that I’m doubting they would require you to prove that would probably be a better strategy if you want to circumvent the recommendations.

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