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  • Originally posted by Tangler View Post
    If you had Johnson and Johnson vaccine (single shot one dose adenovirus DNA vaccine) would you get a booster with moderna?
    Thoughts?
    Thanks.
    Or would a 2 dose series be considered? Any benefit or harm? Is anyone actually recommending J&J?

    Comment


    • Originally posted by Zaphod View Post

      Yet its still lower than 1980, peaked in 1990 and has been getting cheaper /gdp for decades, for over 40 years this has been wrong, yet so many just keep saying stuff as if it wasnt the case.



      It ends with some mild inflation and a perpetual time frame making it irrelevant, same way its always been.

      Also, about 80% of this is held by the public, that is, the 40% of a 60/40 portfolio. Do you want them to take your access to bonds away, or stop paying any interest at all on them?

      Even the nominal payments are tiny compared to past decades ago. This is a nothing burger promoted by charlatans and politicians to fire up the base, on subjects neither of them understand.

      Everyone should do themselves a favor and read a book about monetary policy, Cullen Roche has an excellent one, but his blog is also very good and useful.
      You are correct that the ratio of interest to GDP has remained manageable but that's due to an unprecedented run of abnormally low interest rates. When that ends, the interest/GDP ratio will rise drastically. Another elephant in the room is entitlements. The ratio of entitlements to GDP has risen drastically:

      Click image for larger version

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      Can we raise taxes and boost the economy to keep the train rolling? Maybe
      Will we dramatically roll back entitlements? Doubtful
      Will interest rates continue to stay near zero for ever? No

      Whatever can't go on forever, won't.

      Sorry to hijack the Covid thread, I just couldn't resist responding to your economic comment. I will cease commenting on this topic now. I really do hope you're right about all this but I'm very doubtful.

      Comment


      • Originally posted by Tim View Post

        Or would a 2 dose series be considered? Any benefit or harm? Is anyone actually recommending J&J?
        Some folks got J and J because when they went to get the vaccine that was the only flavor available.

        It was a situation where it was basically J & J or wait. Many chose a single J & J shot vs wait until-----.



        For those folks the question now is: Booster? If so what kind? Moderna seems the best answer in my mind but I don't honestly know and I don't think anyone does.

        As discussed, small trial ongoing:

        https://www.nih.gov/news-events/news...hedules-begins
        Last edited by Tangler; 08-16-2021, 05:03 AM.

        Comment


        • Originally posted by Tangler View Post

          Some folks got J and J because when they went to get the vaccine that was the only flavor available.

          It was a situation where it was basically J & J or wait. Many chose a single J & J shot vs wait until-----.



          For those folks the question now is: Booster? If so what kind? Moderna seems the best answer in my mind but I don't honestly know and I don't think anyone does.

          As discussed, small trial ongoing:

          https://www.nih.gov/news-events/news...hedules-begins
          I realize the allocations originally. The questions still remain. 25 person study in each group is sufficient? This is an extremely small group and Fauci ignores the determination of "IF a booster is needed and how to test". Very weak response to questions that have a huge impact on our lives. It seems actually designed to indicate:
          "Our data indicates that cross using vaccines pose not health risks and increase the effectiveness XXX, XXX". Fill in the blanks seems to be the purpose. Not necessarily any additional knowledge. Please note the question of "booster" and "who needs it" is not answered. Sorry for the rant, Fauci breezed right by that one.
          I have a solution, but he never answered the original question. Surely some data exists or is being developed.

          Comment


          • Got this today from NYS. Not sure if we are going to get any guidance to pass along to patients who ask.

            I feel like I learn about updates from my patients rather than the reverse. They have the time to read/watch the morning news and I am barely up with 2 weeks ago.




            STATEMENT FROM THE NEW YORK STATE DEPARTMENT OF HEALTH

            “As with every emergency use authorization (EUA) of COVID-19 vaccines and subsequent EUA modifications to date, following the CDC’s Advisory Committee on Immunization Practices (ACIP) deliberations and the CDC’s official recommendation yesterday to allow some people with weakened immune systems to receive a third dose of COVID-19 vaccine, the Health Commissioner immediately convened the State’s Clinical Advisory Task Force.

            The Task Force discussed the data presented during the ACIP meeting and reviewed the CDC’s Clinical ​Considerations to inform NYS COVID-19 vaccination program guidance, which will be forthcoming. The Department will complete this process quickly, as it has in the past.

            In the meantime, the Commissioner echoes ACIP’s recommendation that immunocompromised individuals should confer with their physicians regarding the appropriateness and timing for receiving an additional dose of COVID-19 vaccine. Further, the Health Commissioner encourages physicians to proactively reach out to their immunocompromised patients to discuss the benefits of receiving an additional dose.”

            Comment


            • Originally posted by Lordosis View Post
              Got this today from NYS. Not sure if we are going to get any guidance to pass along to patients who ask.

              I feel like I learn about updates from my patients rather than the reverse. They have the time to read/watch the morning news and I am barely up with 2 weeks ago.
              Agreed. I heard about this from one of my patients last week for the first time now getting state board and hospital system updates.

              In oncology, so I get a ton of vaccine and immune related questions from my patients.

              Comment


              • Originally posted by Tangler View Post
                If you had Johnson and Johnson vaccine (single shot one dose adenovirus DNA vaccine) would you get a booster with moderna?
                Thoughts?
                Thanks.
                There's some evidence that people who get one dose of AstraZenica followed by a single dose of an mRNA vaccine 2-3 months later have a better immune response than those who get two doses of either AZ or the mRNA vaccines. J&J isn't AZ, obviously, but it's a similar adenovirus-vector platform, so it makes sense that an mRNA booster might be a good idea.

                Comment


                • Originally posted by artemis View Post

                  There's some evidence that people who get one dose of AstraZenica followed by a single dose of an mRNA vaccine 2-3 months later have a better immune response than those who get two doses of either AZ or the mRNA vaccines. J&J isn't AZ, obviously, but it's a similar adenovirus-vector platform, so it makes sense that an mRNA booster might be a good idea.
                  I saw that data too!

                  Comment


                  • Did I read correctly that the CDC is recommending the same vaccine as original for booster?

                    Comment


                    • Originally posted by Tangler View Post

                      I saw that data too!
                      Makes you wonder whether those of us who received 2 doses of one of the mRNA vaccines would actually be better off getting a booster of J&J. The immune system is such a funny beast...

                      Comment


                      • Originally posted by Lordosis View Post
                        Got this today from NYS. Not sure if we are going to get any guidance to pass along to patients who ask.

                        I feel like I learn about updates from my patients rather than the reverse. They have the time to read/watch the morning news and I am barely up with 2 weeks ago.




                        STATEMENT FROM THE NEW YORK STATE DEPARTMENT OF HEALTH

                        “As with every emergency use authorization (EUA) of COVID-19 vaccines and subsequent EUA modifications to date, following the CDC’s Advisory Committee on Immunization Practices (ACIP) deliberations and the CDC’s official recommendation yesterday to allow some people with weakened immune systems to receive a third dose of COVID-19 vaccine, the Health Commissioner immediately convened the State’s Clinical Advisory Task Force.

                        The Task Force discussed the data presented during the ACIP meeting and reviewed the CDC’s Clinical ​Considerations to inform NYS COVID-19 vaccination program guidance, which will be forthcoming. The Department will complete this process quickly, as it has in the past.

                        In the meantime, the Commissioner echoes ACIP’s recommendation that immunocompromised individuals should confer with their physicians regarding the appropriateness and timing for receiving an additional dose of COVID-19 vaccine. Further, the Health Commissioner encourages physicians to proactively reach out to their immunocompromised patients to discuss the benefits of receiving an additional dose.”
                        I wonder why the NYS DOH latest statement said immunocompromised should get the same mRNA vaccine as a booster shot, but offered no guidance on those who got the J &J shot- "insufficient data to support use of an additional mRNA Covid 19 vaccine dose after single Janssen Covid 19 vaccination in immunocompromised patients"- If J&J is inferior to start with against Covid, shouldnt they also get a booster shot?

                        Comment


                        • Originally posted by billy View Post

                          I wonder why the NYS DOH latest statement said immunocompromised should get the same mRNA vaccine as a booster shot, but offered no guidance on those who got the J &J shot- "insufficient data to support use of an additional mRNA Covid 19 vaccine dose after single Janssen Covid 19 vaccination in immunocompromised patients"- If J&J is inferior to start with against Covid, shouldnt they also get a booster shot?
                          I was thinking the same. I imagine that will be the recommendation in a few weeks.

                          My area had a pretty good mix of the 3 vaccines so people took what they could get at the time.

                          Now I am seeing a pickup in the J&J because it is the people who really do not want to be vaccinated but "have to" for some reason and choose the 1 shot.

                          Comment


                          • Originally posted by Lordosis View Post

                            I was thinking the same. I imagine that will be the recommendation in a few weeks.

                            My area had a pretty good mix of the 3 vaccines so people took what they could get at the time.

                            Now I am seeing a pickup in the J&J because it is the people who really do not want to be vaccinated but "have to" for some reason and choose the 1 shot.
                            In the mean time, necessity is the mother of invention. It is about time for one of the WCI secret weapons scientific methods.

                            THE LORDOSIS FINAL DEFINITIVE COVID BOOSTER VACCINATION POLL.

                            Under development? Everything the world needs to know about vaccines, boosters and evidenced based vaccine data. The world needs to know. Vote as often and no qualifications needed. Just an anonymous internet vote. Fair and balanced and as reliable as any other method.

                            Comment


                            • I was just talking to my wife (employment lawyer) about how the booster will affect workplace policy, specifically, will there be a distinction between people who have had booster vs. not, going forward. (They are having enough trouble getting people vaccinated in the first place.) Extrapolate this to Hospitals, cruises, NFL players and stadiums, etc. Will there be a time later this year when "fully vaccinated" means 3 shots? Or will it depend on the timing of the shots? And then throw the JNJ vaccine into the mix. What a policy mess!

                              Comment


                              • I can see a yearly booster like the flu shot coming around the workplace policies, but for now, just getting people vaccinated is key.

                                ps- just informed my friend who had pfizer in march has a breakthrough case. Constantly hanging out with our one unvaccinated friend, who I have refused to hang out with this whole time. Or maybe caught it walking down the street who knows.

                                Comment

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